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What is the DOPAC ?
DOPAC is beige to light brown crystalline powder, while it's Molecular Formula is C8H8O4. 3,4-Dihydroxyphenylacetic acid is an important metabolite when studying the behavior of the dopaminergic system.
What is the CAS number for DOPAC ?
The CAS number of DOPAC is 102-32-9.
More information of DOPAC 102-32-9 are:
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Synonyms |
Aceticacid, (3,4-dihydroxyphenyl)- (8CI);(3,4-Dihydroxyphenyl)acetic acid;3,4-Dihydroxybenzeneacetic acid;Ba 2773;DOPAC;Dihydroxyphenylacetic acid;Dopacetic acid;Homoprotocatechuic acid;NSC 73191; |
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CAS?Number |
102-32-9 |
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Molecular Formula |
C8H8O4 |
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Molecular Weight |
168.149 |
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Density |
1.478 g/cm3 |
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Melting Point |
127-130 °C(lit.) |
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Boiling Point |
418.4 °C at 760 mmHg |
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Flash Point |
221 °C |
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HS CODE |
29182900 |
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PSA |
77.76000 |
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LogP |
0.72490 |
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Pka |
4.42±0.10(Predicted) |
What is DOPAC (102-32-9) used for?
3,4-Dihydroxyphenylacetic acid (DOPAC) is a metabolite of the neurotransmitter dopamine. Dopamine can be metabolized into one of three substances. One such substance is DOPAC. Another is 3-methoxytyramine (3-MT). Both of these substances are degraded to form homovanillic acid (HVA). Both degradations involve the enzymes monoamine oxidase (MAO) and catechol-O-methyl transferase (COMT), albeit in reverse order: MAO catalyzes dopamine to DOPAC, and COMT catalyzes DOPAC to HVA; whereas COMT catalyzes dopamine to 3-MT and MAO catalyzes 3-MT to HVA. The third metabolic end-product of dopamine is norepinephrine (noradrenaline).DOPAC can be oxidized by hydrogen peroxide, leading to the formation of toxic metabolites which destroy dopamine storage vesicles in the substantia nigra. This may contribute to the failure of levodopa treatment of Parkinson's disease. A MAO-B inhibitor such as selegiline or rasagiline can prevent this from happening.wikipedia
InChI:InChI=1/C8H8O4/c9-7(10)8(11,12)6-4-2-1-3-5-6/h1-5,11-12H,(H,9,10)
Articles related to DOPAC:
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Article |
Source |
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Hydroxylation of p-substituted phenols by tyrosinase: Further insight into the mechanism of tyrosinase activity |
Munoz-Munoz, Jose Luis,Berna, Jose,Garcia-Molina, Maria del Mar,Garcia-Molina, Francisco,Garcia-Ruiz, Pedro Antonio,Varon, Ramon,Rodriguez-Lopez, Jose N.,Garcia-Canovas, Francisco , p. 228 - 233 (2012) |
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A kinetic investigation of the pulmonary metabolism of dopamine in rats shows marked differences compared with noradrenaline |
Scarcella,Bryan-Lluka , p. 491 - 499 (1995) |
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