Organic Chemicals
Current location:Home > Organic Chemicals
Cost-effective and customizable 2-Fluorobenzylamine 89-99-6 in stock
- Molecular Formula: C7H8FN
- Molecular Weight: 125.146
- Appearance/Colour: clear colorless to yellow liquid
- Vapor Pressure: 7.84E-05mmHg at 25°C
- Melting Point: 245-246 °C(Solv: N,N-dimethylformamide (68-12-2))
- Refractive Index: n20/D 1.517(lit.)
- Boiling Point: 185.9 °C at 760 mmHg
- PKA: 8?+-.0.10(Predicted)
- Flash Point: 67.2 °C
- PSA： 26.02000
- Density: 1.101 g/cm3
- LogP: 1.98470
2-Fluorobenzylamine(Cas 89-99-6) Usage
|
General Description |
2-Fluorobenzylamine is a key intermediate in the synthesis of 9-(2-fluorobenzyl)-6-methylamino-9H-purine, a potent anticonvulsant agent. It serves as a precursor in multiple synthetic routes, particularly in the condensation with 5-amino-4,6-dichloropyrimidine, followed by further transformations to yield the target compound. Its role underscores its importance in medicinal chemistry for the development of bioactive purine derivatives. |
InChI:InChI=1/C8H10BFO3/c1-2-13-8-5-6(9(11)12)3-4-7(8)10/h3-5,11-12H,2H2,1H3
89-99-6 Relevant articles
Palladium-catalyzed ortho -selective C-H fluorination of oxalyl amide-protected benzylamines
Chen, Changpeng,Wang, Chao,Zhang, Jingyu,Zhao, Yingsheng
, p. 942 - 949 (2015)
A novel and efficient synthetic method f...
Generation of Oxidoreductases with Dual Alcohol Dehydrogenase and Amine Dehydrogenase Activity
Tseliou, Vasilis,Schilder, Don,Masman, Marcelo F.,Knaus, Tanja,Mutti, Francesco G.
supporting information, p. 3315 - 3325 (2020/12/11)
The l-lysine-?-dehydrogenase (LysEDH) fr...
Method for preparing primary amine by catalyzing reductive amination of aldehyde ketone compounds
-
Paragraph 0027-0030; 0051-0055, (2020/05/30)
The invention discloses a method for pre...
Ultra-small cobalt nanoparticles from molecularly-defined Co-salen complexes for catalytic synthesis of amines
Beller, Matthias,Chandrashekhar, Vishwas G.,Gawande, Manoj B.,Jagadeesh, Rajenahally V.,Kalevaru, Narayana V.,Kamer, Paul C. J.,Senthamarai, Thirusangumurugan,Zbo?il, Radek
, p. 2973 - 2981 (2020/03/27)
We report the synthesis of in situ gener...
PROCESS FOR PREPARATION OF HALOGENATED BENZYLAMINE AND INTERMEDIATES THEROF
-
Page/Page column 17, (2020/08/13)
The present invention provides an improv...
89-99-6 Process route
-
-
446-52-6
2-Fluorobenzaldehyde
-
-
446-51-5
2-fluorobenzyl alcohol
-
-
89-99-6
2-fluorobenzylamine
Conditions
| Conditions | Yield |
|---|---|
|
With
ammonium hydroxide; ammonium acetate; hydrogen;
[Ru(cod)Cl]2; trisodium tris(3-sulfophenyl)phosphine;
In
tetrahydrofuran;
at 135 ℃;
for 2h;
under 48754.9 Torr;
|
58 % Chromat.
9 % Chromat. |
-
-
446-52-6
2-Fluorobenzaldehyde
-
-
89-99-6
2-fluorobenzylamine
Conditions
| Conditions | Yield |
|---|---|
|
With
Candida boidinii formate dehydrogenase; Geobacillus stearothermophilus ε‐deaminating L‐lysine dehydrogenase variant 22; nicotinamide adenine dinucleotide;
In
aq. buffer;
at 30 ℃;
for 24h;
pH=8.5;
Reagent/catalyst;
Enzymatic reaction;
|
99%
|
|
With
N,N'-bis(salicylidene)-1,2-phenylene-diaminocobalt(II); ammonia; hydrogen;
In
tetrahydrofuran; water;
at 120 ℃;
for 24h;
Autoclave;
|
86%
|
|
2-Fluorobenzaldehyde;
With
Rink resin; trimethyl orthoformate;
at 25 ℃;
for 2h;
With
lithium borohydride;
In
tetrahydrofuran;
at 65 ℃;
for 5h;
With
trifluoroacetic acid;
In
dichloromethane;
at 25 ℃;
|
|
|
With
L-alanin; pyridoxal 5'-phosphate; halomonas elongata transaminase Y149F mutant;
In
aq. phosphate buffer; dimethyl sulfoxide;
at 37 ℃;
for 24h;
pH=8;
Reagent/catalyst;
Enzymatic reaction;
|
89-99-6 Upstream products
-
446-48-0
o-fluorobenzyl bromide
-
394-47-8
2-fluorobenzonitrile
-
446-52-6
2-Fluorobenzaldehyde
-
95-52-3
2-Fluorotoluene
89-99-6 Downstream products
-
56000-53-4
2-(2-Fluoro-benzylamino)-2-[(Z)-hydroxyimino]-N,N-dimethyl-acetamide
-
704-98-3
N-(2-Fluoro-benzyl)-guanidine
-
101155-07-1
5-Amino-4-chloro-6-(2-fluorobenzylamino)pyrimidine
-
926257-13-8
2-Amino-N-(2-fluoro-benzyl)-benzamide
WANT TO
PURCHASE