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17,21-dihydroxy-16beta-methylpregna-1,4,9(11)-triene-3,20-dione 21-acetate
- CAS No.: 910-99-6
- Purity: 99%
Factory Sells Best Quality 17,21-dihydroxy-16beta-methylpregna-1,4,9(11)-triene-3,20-dione 21-acetate 910-99-6 with USP
- Molecular Formula: C24H30 O5
- Molecular Weight: 398.499
- Vapor Pressure: 7.12E-15mmHg at 25°C
- Melting Point: 205-207 °C
- Boiling Point: 560°C at 760 mmHg
- PKA: 12.48±0.70(Predicted)
- Flash Point: 189.6°C
- PSA: 80.67000
- Density: 1.22g/cm3
- LogP: 3.32370
17,21-dihydroxy-16beta-methylpregna-1,4,9(11)-triene-3,20-dione 21-acetate(Cas 910-99-6) Usage
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General Description |
17,21-dihydroxy-16beta-methylpregna-1,4,9(11)-triene-3,20-dione 21-acetate is a synthetic corticosteroid and derivative of cortisol that is used in the treatment of various inflammatory and autoimmune conditions. It acts as a potent anti-inflammatory and immunosuppressive agent by inhibiting the release of inflammatory cytokines and suppressing the activity of immune cells. The addition of the acetate group enhances its stability and prolongs its duration of action in the body. This chemical is commonly used in the form of creams, ointments, and inhalers for topical and localized treatment of skin conditions, asthma, and allergic reactions, as well as in oral or injectable formulations for systemic conditions such as rheumatoid arthritis, lupus, and inflammatory bowel disease. Despite its effectiveness, it can also cause several side effects such as skin thinning, increased risk of infections, and adrenal suppression, and should only be used under the supervision of a healthcare professional. |
InChI:InChI=1/C24H30O5/c1-14-11-20-18-6-5-16-12-17(26)7-9-22(16,3)19(18)8-10-23(20,4)24(14,28)21(27)13-29-15(2)25/h7-9,12,14,18,20,28H,5-6,10-11,13H2,1-4H3/t14-,18+,20-,22-,23-,24-/m0/s1
910-99-6 Relevant articles
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Page/Page column 43-44, (2019/11/18)
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, (2017/01/19)
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Betamethasone intermediates or its preparation method of the analogue
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, (2016/12/22)
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910-99-6 Process route
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(Z)-2-((10S,13S,16R)-10,13,16-trimethyl-3-oxo-7,8,12,13,15,16-hexahydro-3H-cyclopenta[a]phenanthren-17(6H,10H,14H)-ylidene)-2-(trimethylsilyloxy)ethyl acetate
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910-99-6,10106-41-9,98573-84-3
2-((10S,13S,16R,17R)-17-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,10,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
| Conditions | Yield |
|---|---|
|
With
3-chloro-benzenecarboperoxoic acid;
In
dichloromethane;
at 0 ℃;
for 4h;
|
|
|
With
3-chloro-benzenecarboperoxoic acid;
In
dichloromethane;
at 0 ℃;
for 4h;
|
|
|
With
3-chloro-benzenecarboperoxoic acid;
In
dichloromethane;
at 0 ℃;
for 4h;
|
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-
2-((10S,13S,16R)-10,13,16-trimethyl-3-oxo-7,8,12,13,15,16-hexahydro-3H-cyclopenta[a]phenanthren-17(6H,10H,14H)-ylidene)-2-(trimethylsilyloxy)ethyl acetate
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-
910-99-6,10106-41-9,98573-84-3
2-((10S,13S,16R,17R)-17-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,10,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
| Conditions | Yield |
|---|---|
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2-((10S,13S,16R)-10,13,16-trimethyl-3-oxo-7,8,12,13,15,16-hexahydro-3H-cyclopenta[a]phenanthren-17(6H,10H,14H)-ylidene)-2-(trimethylsilyloxy)ethyl acetate;
With
peracetic acid;
In
acetic acid; toluene;
at -10 ℃;
With
sodium hydrogensulfite; trifluoroacetic acid;
|
|
|
With
3-chloro-benzenecarboperoxoic acid;
In
dichloromethane;
at 0 ℃;
for 4h;
|
910-99-6 Upstream products
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37413-91-5
2-((10S,13S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
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2597-76-4
16β-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione
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64-19-7
acetic acid
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142575-10-8
C24 H29 NO2
910-99-6 Downstream products
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13209-41-1
(10S,13S,16R,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,10,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-3-one
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912-38-9
21-acetoxy-9,11β-epoxy-17-hydroxy-16β-methyl-9β-pregna-1,4-diene-3,20-dione
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987-24-6
betamethasone 21-acetate
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